反应详情

10 Grams of 6-carboxy-3,4-dihydrocarbostyril and 6.0 g of N-hydroxysuccinimide were suspended in 200 ml of dioxane. Then a solution containing 12.4 g of dicyclohexylcarbodiimide in 50 ml of dioxane was added dropwise thereto under ice-cooled condition with stirring. The reaction mixture was further stirred for 4 hours at 90° C. After the reaction was completed, the reaction mixture was allowed to stand to cool at room temperature, and the crystals precipitated were removed by filtration, then the filtrate obtained was concentrated to dryness. The residue was recrystallized from dimethylformamide-ethanol to obtain 10.8 g of succinimide 3,4-dihydrocarbostyril-6-carboxylate in the form of colorless flake-like crystals.

1. additionwas added dropwise
2. temperatureunder ice-cooled condition
3. stirringThe reaction mixture was further stirred for 4 hours at 90° C
4. customthe crystals precipitated
5. customwere removed by filtration
6. customthe filtrate obtained
7. concentrationwas concentrated to dryness
8. customThe residue was recrystallized from dimethylformamide-ethanol