Methanol → HCID 13342142, compound

HRID 483181Notes

Reaction equation

HRID 483181 reaction equation
Cl.[NH2:2][CH:3]([CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10](=[O:18])[CH:9]=1)[C:4]([OH:6])=[O:5].S(Cl)(Cl)=O.[CH3:23]O>>[NH2:2][CH:3]([CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10](=[O:18])[CH:9]=1)[C:4]([O:6][CH3:23])=[O:5]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 11514549HCID 11514549, compound

Product 1

HCID 13342142HCID 13342142, compound

Procedure

4 Grams of 2-amino-3-(2-quinolon-4-yl)propionic acid hydrochloride was suspended in 50 ml of methanol. Under an ice-cooled condition with strring, 5.3 g of thionyl chloride was added dropwise thereto, the reaction mixture was stirred at a room temperature overnight. Methanol and thionyl chloride were removed by distillation under a reduced pressure, then the residue obtained was recrystallized from methanolacetone to obtain 2.4 g of methyl 2-amino-3-(2-quinolon-4-yl)propionate in the form of white powdery product.

Workup

  1. additionwas added dropwise
  2. customMethanol and thionyl chloride were removed by distillation under a reduced pressure
  3. customthe residue obtained
  4. customwas recrystallized from methanolacetone

Sources & evidence

ORD record
ord-ad2b5b036bbc4921920f24f3bd555b2d
Source dataset
uspto-grants-1986_03
Patent number
US04578381

Reaction notes

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