Hydrochloric Acid → HCID 13471557, compound

Participants

Reaction Steps

2.0 Grams of 2-amino-3-(6-hydroxy-2-quinolon-4-yl)propionic acid hydrochloride and 4.8 g of potassium carbonate were dissolved in 100 ml of aceton with 50 ml of water. To this mixture was added 2.7 g of p-chlorobenzoyl chloride was added dropwise under ice-cooled condition with stirring. The reaction was continued for 3 hours under ice-cooled condition with stirring. Acetone was removed by distillation, the residue obtained was diluted with water, acidified with hydrochloric acid. The crystals precipitated were collected by filtration. Recrystallized from ethanol-water to obtain 1.5 g of 2-(4-chlorobenzoylamino)3-[6-(4-chlorobenzoyloxy)-2-quinolon-4-yl]propionic acid in the form of white powdery product.

Provenance & Evidence