Diketene → HCID 10108340, compound

HRID 483192Notes

Reaction equation

HRID 483192 reaction equation
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH2:7]([N:14]([CH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[CH3:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1C=CC=CC=1>[C:4]([O:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][N:14]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:15])(=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

Participants

4

Reactant 2

HCID 12661DiketeneHCID 13422168HCID 13422168, compound

Product 1

HCID 10108340HCID 10108340, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

One gram of diketen was added dropwise to a stirred solution of 3-(N-benzyl-N-methylamino)-2,2-dimethyl propanol in 1 ml of benzene at 70° C. Sturing was continued for 1.5 hours at 70° C. after the addition. The solvent was distilled off to leave an oily residue. The residue was chromatographed over silica gel to afford 2.8 g of desired 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate (oily substance).

Workup

  1. additionafter the addition
  2. distillationThe solvent was distilled off
  3. customto leave an oily residue
  4. customThe residue was chromatographed over silica gel

Sources & evidence

ORD record
ord-9bf57e4daab84dd3bbcec133d8830958
Source dataset
uspto-grants-1986_03
Patent number
US04578395

Reaction notes

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