Ammonia → HCID 13504496, compound

HRID 483193Notes

Reaction equation

HRID 483193 reaction equation
[C:1]([O:7][CH2:8][C:9]([CH3:21])([CH3:20])[CH2:10][N:11]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:12])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[NH3:22]>C(O)C>[NH2:22]/[C:3](/[CH3:5])=[CH:2]\[C:1]([O:7][CH2:8][C:9]([CH3:21])([CH3:20])[CH2:10][N:11]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:12])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10108340HCID 10108340, compound

Product 1

HCID 13504496HCID 13504496, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5.07 g of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 15 ml of ethanol was cooled with ice-water. The solution was bubled gasous ammonia and then stirred at room temperature. The solution stood at room temperature overnight. To the solution was added ice-water, and then a precipitated white solid was removed. The solid was washed with water and dried under reduced pressure to yield 4.79 g of the desired compound.

Workup

  1. customa precipitated white solid was removed
  2. washThe solid was washed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-27dd46d218484656aeabe6e73b4a9ef5
Source dataset
uspto-grants-1986_03
Patent number
US04578395

Reaction notes

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