HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 70456982, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate | HCID 10108340 | — |
| Reactant | 3-CHLORO-2-NITROBENZALDEHYDE | HCID 12248972 | — |
| Product | HCID 70456982 | HCID 70456982 | — |
Reaction Steps
A mixture of 185 mg of 3-chloro-2-nitrobenzaldehyde, 118 mg of methyl 3-aminocrotonate and 292 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 1 ml of 2-propanol was refluxed for 12 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a method of column chromatography on silica gel to yield 337 mg of the desired compound (132).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578395 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-7c373083ce3d4fbb96d390ffc50abd9a |
| Source note | uspto-grants-1986_03 |