HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-aminocrotonate → HCID 10347672, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate | HCID 10108340 | — |
| Reactant | 2-Chloro-3-nitrobenzaldehyde | HCID 12667713 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 10347672 | HCID 10347672 | 51.9% |
Reaction Steps
A mixture of 128.7 mg of 2-chloro-3-nitrobenzaldehyde, 88 mg of methyl 3-aminocrotonate and 220 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 1 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to yield 200 mg of desired compound (136).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578395 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-5085f0ec63264fc68ea07d1696a645f9 |
| Source note | uspto-grants-1986_03 |