反应详情

温度

60 °C

5-Benzyl-6-methylthiouracil (6.0 gms) and sodium hydroxide (1.06 gms) were dissolved in water (30 mls). The solution was cooled and ethanol (60 mls) and methyl iodide (3.67 gms) added with stirring. The mixture was heated at 60° C. for 1/2 hour, cooled and the resulting solid collected and water-washed. A second crop of solid was obtained by acidification of the filtrate to pH=4 with acetic acid. Recrystallisation from ethanol produced 5-benzyl-6-methyl-2-methylthio-4-pyrimidone (5.53 gms) m.p.=220°-221.5° C.

1. temperatureThe solution was cooled
2. temperaturecooled
3. customthe resulting solid collected
4. washwater-washed
5. customA second crop of solid was obtained by acidification of the filtrate to pH=4 with acetic acid
6. customRecrystallisation from ethanol