Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Malonic acid, (trifluoromethyl)-, dimethyl ester | HCID 201364 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 12958004 | HCID 12958004 | 73.5% |
Reaction Steps
A mixture of dimethyl(trifluoromethyl)malonate (4.0 g, 20 mmol), methyl vinyl ketone (1.54 g, 22 mmol), triethylamine (0.30 g, 3 mmol), and pyridine (20 ml) was heated for 4 h at 70° C. The reaction mixture was poured into water and worked up as usual. The adduct, dimethyl 1,1,1-trifluoro-5-oxo-2,2-hexanedicarboxylate (3.97 g), b.p. 88°-89° C./0.2 mmHg, was obtained and identified in a similar way.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04578503 |
|---|
| Source dataset | uspto-grants-1986_03 |
|---|
| ORD ID | ord-0ff7d8b494f04b05a628f8b68285cc3a |
|---|
| Source note | uspto-grants-1986_03 |
|---|
