HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-fluorobenzoic acid → (8-Chloro-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-fluorobenzoic acid | HCID 99152 | — |
| Reactant | (1-Methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester | HCID 72957243 | — |
| Product | (8-Chloro-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester | HCID 86585812 | — |
Reaction Steps
(8-chloro-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester was prepared in an analogous fashion to (1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester, as described in Example 1 by replacing 2-fluorobenzoic acid with 4-chloro-2-fluorobenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703387B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-cafcf1e2c6564f24b4144d972fce84b7 |
| Source note | uspto-grants-2004_03 |