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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 483280Generated: October 25, 2026

Dimethyl Sulfoxide → 2-trifluoromethylphenyl-S,S-dimethylsulfilimine

https://huagongshe.com/reaction/483280

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfoxideHCID 679—
Reactant2-Nitro-alpha,alpha,alpha-trifluorotolueneHCID 9795—
Reactant2-(Trifluoromethyl)phenyl isocyanateHCID 16794—
Product2-trifluoromethylphenyl-S,S-dimethylsulfilimineHCID 13391192—

Reaction Steps

The process of claim 18 in which 2-trifluoromethylnitrobenzene is carbonylated to 2-trifluoromethylphenyl isocyanate, which is reacted with dimethylsulfoxide to obtain N-(2-trifluoromethylphenyl)-S,S-dimethylsulfilimine, rearranged to a 2-(methylthiomethyl)-6-trifluoromethylaniline, and desulfurized to 2-methyl-6-trifluoromethyl aniline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04578514
Source datasetuspto-grants-1986_03
ORD IDord-564a0531b1c74f918c075c91dda58357
Source noteuspto-grants-1986_03