2-Amino-3-(methylthiomethyl)benzotrifluoride → 2-Amino-3-methylbenzotrifluoride
Reaction equation
FC(F)(F)C1C=CC=CC=1N=S(C)C.CS[CH2:17][C:18]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[C:19]=1[NH2:20]>>[CH3:17][C:18]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:26])([F:27])[F:28])[C:19]=1[NH2:20]Participants
3
Procedure
The process of claim 18 in which 2-methyl-6-trifluoromethyl aniline is prepared by reacting 1-nitro-2-trifluromethylbenzene with carbon monoxide at elevated pressure over a noble metal catalyst to obtain 2-trifluoromethylphenyl isocyanate, such isocyanate is reacted with dimethyl sulfoxide in the presence of strong acid to produce 2-trifluoromethylphenyl-S,S-dimethylsulfilimine; the sulfilimine is rearranged in the presence of a rearrangement catalyst to 2-methylthiomethyl-6-trifluoromethylaniline and desulfurized under reductive conditions to obtain 2-methyl-6-trifluoromethylaniline.
Sources & evidence
- ORD record
- ord-8ca3c3203c32454da2565473b7ea1bd6
- Source dataset
- uspto-grants-1986_03
- Patent number
- US04578514
Reaction notes
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