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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 48333Generated: October 25, 2026

2,4-Difluorobenzoic acid → (8-Fluoro-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester

https://huagongshe.com/reaction/48333

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-Difluorobenzoic acidHCID 74102—
Reactant(1-Methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl esterHCID 72957243—
Product(8-Fluoro-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl esterHCID 86585813—

Reaction Steps

The starting material (8-fluoro-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]-diazepin-5-ylidenemethyl)phosphonic acid diethyl ester was prepared in an analogous fashion to (1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester, as described in Example 1 by replacing 2-fluorobenzoic acid with 2,4-difluorobenzoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06703387B2
Source datasetuspto-grants-2004_03
ORD IDord-abc16f3cc58d4f7da8d4f0a457a7dbba
Source noteuspto-grants-2004_03