Potassium bisulfate → HCID 19752432, compound

HRID 483342Notes

Reaction equation

HRID 483342 reaction equation
[C:1]([C:4]1[C:21]([OH:22])=[CH:20][C:7]([O:8][CH2:9][C:10]2[N:15]=[C:14]([C:16]([O:18]C)=[O:17])[CH:13]=[CH:12][CH:11]=2)=[C:6]([CH2:23][CH3:24])[CH:5]=1)(=[O:3])[CH3:2].S(=O)(=O)(O)[O-].[K+]>CO.[OH-].[Na+]>[C:1]([C:4]1[C:21]([OH:22])=[CH:20][C:7]([O:8][CH2:9][C:10]2[N:15]=[C:14]([C:16]([OH:18])=[O:17])[CH:13]=[CH:12][CH:11]=2)=[C:6]([CH2:23][CH3:24])[CH:5]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 516920Potassium bisulfateHCID 19752429HCID 19752429, compound

Product 1

HCID 19752432HCID 19752432, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

Methyl 6-[(4-acetyl-2-ethyl-5-hydroxyphenoxy)methyl]pyridine-2-carboxylate (38 mg, 12 mmol) was dissolved in a methanol solution (2 ml), and one normal sodium hydroxide (1 ml) was added to the above solution at 0° C., and the mixture was stirred at room temperature for 1 hour. One-tenth normal potassium bisulfate was titrated to the above solution until it became pH2. Then, precipitated white crystals were separated by filtration, and washed with water, and dried to give 6-[(4-acetyl-2-ethyl-5-hydroxyphenoxy)methyl]pyridine-2-carboxylic acid.

Workup

  1. additionwas added to the above solution at 0° C.
  2. customThen, precipitated white crystals
  3. customwere separated by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-0655723e68924c9f8147fdcd4948db3e
Source dataset
uspto-grants-1993_07
Patent number
US05225422

Reaction notes

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