Hydrogen Bromide → HCID 19752458, compound

Participants

Reaction Steps

solution of 5 g of m-aminoacetophenone in 100 ml of acetone was combined with 25 ml of water and 15 ml of 47% hydrobromic acid and the resultant mixture was stirred for 30 minutes with 10 ml of an aqueous solution containing 3.32 g of sodium nitrite added dropwise in advance thereto at 5 C. The produced reaction solution and 28 ml of ethyl acrylate added dropwise thereto and 0.53 g of copper (I) oxide added piecemeal thereto at 40° C. were stirred for 2 hours. The resultant mixture was combined with water, extracted with ethyl acetate An organic layer was washed with water and a saturated aqueous saline solution, dried with anhydrous magnesium sulfate, and distilled under a vacuum to expel the solvent to obtain ethyl 2-bromo-3-(3-acetylphenyl)propionate.

Provenance & Evidence