4-Nitro-3-phenyl-L-alanine → HCID 9996417, compound

Participants

Reaction Steps

Benzyl isocyanate (3.2 g, Aldrich) was added dropwise at 0° C. over 20 minutes to a stirred mixture of p-nitrophenylalanine (4.2 g, Fluka) and KOH (1.3 g) in water (40 ml). When addition was complete, the mixture was stirred at 60°-70° C. for 2 hours, then cooled, filtered, and the filtrate treated with c.HCl. The resulting white solid was filtered off, washed with ice-water, dried in vacuo, then suspended in 50% aqu. HCl (20 ml) and refluxed for 2 hours. The suspension was cooled, diluted with water, filtered, and the residue dried in vacuo to give the desired product (5.7 g).

Provenance & Evidence