HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → Agomelatine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 7-Methoxy-1-naphthaleneethanamine | HCID 11052667 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Agomelatine | HCID 82148 | — |
Reaction Steps
0.01 ml of 2-(7-methoxynaphth-1-yl)ethylamine is dissolved in 6 ml of pyridine. The mixture is cooled in an ice bath with agitation, and 0.012 mol of acetyl chloride is added dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05225442 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-1499dc78fc0d4de7abaf31eec2bc66e3 |
| Source note | uspto-grants-1993_07 |