反应详情

A solution of 1.5 g (0.0058 mole) of 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one in 20 ml of dimethylamine was stirred at 25° C. in a sealed container for 72 hr. The excess dimethylamine was allowed to evaporate and the residue was partitioned between chloroform and dilute sodium hydroxide. The chloroform layer was concentrated and the residue, the free base of the title compound, was dissolved in isopropyl alcohol and reacted with hydrogen chloride. The resulting hydrochloride salt weighted 1.5 g (77%), m.p.>250° C.

1. customto evaporate
2. customthe residue was partitioned between chloroform and dilute sodium hydroxide
3. concentrationThe chloroform layer was concentrated
4. dissolutionthe residue, the free base of the title compound, was dissolved in isopropyl alcohol
5. customreacted with hydrogen chloride