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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 483415Generated: October 31, 2026

1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride → 1-(p-Chlorobenzyl)-alpha,alpha-dimethyl-5-fluoro-3-methylthioindole-2-propanoic acid

https://huagongshe.com/reaction/483415

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochlorideHCID 14591242—
ReactantMethyl 2,2-dimethyl-5-methylthio-4-oxopentanoateHCID 15035406—
Product1-(p-Chlorobenzyl)-alpha,alpha-dimethyl-5-fluoro-3-methylthioindole-2-propanoic acidHCID 15035387—

Reaction Steps

Following the procedure of Example 10, but using 1-(p-chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride and methyl-2,2-dimethyl-5-methylthio-4-oxopentanoate as starting materials and hydrolysis at reflux, the title compound was prepared, mp 161°-163°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05225421
Source datasetuspto-grants-1993_07
ORD IDord-edea355ae4f64b468d061603a0d0fc87
Source noteuspto-grants-1993_07