HRID483421

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C(C)(C)CC(=O)CSc1nc2cc(Cl)ccc2s1

HCID15035415

未命名化合物

HCID19752394

1-[(4-Chlorophenyl)methyl]-1-[4-(propan-2-yl)phenyl]hydrazine--hydrogen chloride (1/1)

C16H20Cl2N2

PRODUCTS

生成物

结构：CC(C)c1ccc2c(c1)c(Sc1nc3cc(Cl)ccc3s1)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1

HCID11273255

未命名化合物

PROCEDURE

实验过程

Following the procedure of Example 104, but 1-(p-chlorobenzyl)-1-[4-(i-propyl)phenyl]-hydrazine hydrochloride and methyl 2,2-dimethyl-4-oxo-5-(5-chlorobenzothiazol-2-ylthio)pentanoate as starting materials followed by hydrolysis at reflux gave the title compound, m.p 154°-156°.

WORKUP

后处理

customfollowed by hydrolysis
temperatureat reflux

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf643c16d8ae4de4a43c87ce30c8dff0
来源数据集: uspto-grants-1993_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05225421
来源说明: uspto-grants-1993_07

反应 SMILES

Cl.[Cl:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([CH3:18])[CH3:17])=[CH:12][CH:11]=2)N)=[CH:5][CH:4]=1.[CH3:21][C:22]([CH3:42])([CH2:27][C:28](=O)[CH2:29][S:30][C:31]1[S:32][C:33]2[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][C:34]=2[N:35]=1)[C:23]([O:25]C)=[O:24]>>[Cl:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:10]3[C:15](=[CH:14][C:13]([CH:16]([CH3:18])[CH3:17])=[CH:12][CH:11]=3)[C:29]([S:30][C:31]3[S:32][C:33]4[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][C:34]=4[N:35]=3)=[C:28]2[CH2:27][C:22]([CH3:42])([CH3:21])[C:23]([OH:25])=[O:24])=[CH:5][CH:4]=1