Thionyl Chloride → HCID 53659360, compound

HRID 483532Notes

Reaction equation

HRID 483532 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][CH2:13][C:11]2=[O:12])=[CH:6][CH:5]=1)(O)=[O:2].S(Cl)([Cl:23])=O>C(Cl)(Cl)Cl>[N:10]1([C:7]2[CH:8]=[CH:9][C:4]([C:1]([Cl:23])=[O:2])=[CH:5][CH:6]=2)[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][C:11]1=[O:12]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19030984HCID 19030984, compound

Product 1

HCID 53659360HCID 53659360, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 1-(4-carboxyphenyl)-3,4-dihydrocarbostyril (0.2 g) in chloroform (5 ml) is added thionyl chloride (0.8 ml) and the mixture is refluxed with heating for 1 hour. Then, chloroform and thionyl chloride are distilled off under reduced pressure to give 4-(3,4-dihydrocarbostyril-1-yl)benzoic acid chloride.

Workup

  1. temperaturethe mixture is refluxed
  2. temperaturewith heating for 1 hour
  3. distillationThen, chloroform and thionyl chloride are distilled off under reduced pressure

Sources & evidence

ORD record
ord-3edf9e5c0230488699a75dcfec49f6b2
Source dataset
uspto-grants-1993_07
Patent number
US05225402

Reaction notes

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