HRID483565

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID137980

Thiazole, 5-methyl-

C4H5NS

结构：CCCCCCCCCCCCCCOc1ccc(CN(C(C)=O)c2cccc(CBr)c2)cc1

HCID10414650

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(CN(C(C)=O)c2cccc(C[n+]3csc(C)c3)c2)cc1.[Br-]

HCID10371820

未命名化合物

收率 87.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

A mixture of 3 g of N-[3-(bromomethyl)phenyl]-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide and 2.24 g of 5-methylthiazole in 40 ml of toluene is refluxed for 4 hours, cooled and diluted with 60 ml of ether and allowed to stand at room temperature overnight. The solid is collected by centrifugation and washed three times with ether then vacuum dried to give 3.1 g of the desired product as a white powder, m.p. 130°-134° C.

WORKUP

后处理

temperatureis refluxed for 4 hours
temperaturecooled
customThe solid is collected by centrifugation
washwashed three times with ether
customvacuum dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b4f05f7986e84ce2b9c66cc09b327cd0
来源数据集: uspto-grants-1993_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05225425
来源说明: uspto-grants-1993_07

反应 SMILES

[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:16][CH:15]=2)[C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1.[CH3:35][C:36]1[S:40][CH:39]=[N:38][CH:37]=1>C1(C)C=CC=CC=1.CCOCC>[Br-:1].[C:10]([N:9]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:16][CH:15]=1)[C:5]1[CH:4]=[C:3]([CH2:2][N+:38]2[CH:37]=[C:36]([CH3:35])[S:40][CH:39]=2)[CH:8]=[CH:7][CH:6]=1)(=[O:12])[CH3:11]