HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 4-Chloro-2,6-di(pyrrolidin-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2,4,6-Trichloropyrimidine | HCID 77378 | — |
| Product | 4-Chloro-2,6-di(pyrrolidin-1-yl)pyrimidine | HCID 703699 | 74% |
Reaction Steps
U.S. Pat. No. 4,996,318 discloses that treatment of 2,4,6-trichloropyrimidine (I) with pyrrolidine (II) at 20°-25° for 4 hrs gives 2,4-di(1-pyrrolidinyl)-6-chloropyrimidine (III) in 74.0% yield. The yield of 4,6-di(1-pyrrolidinyl)-2-chloropyrimidine (IV) was not disclosed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05225555 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-35b0a6fdbeea4eea93e69a08e797f881 |
| Source note | uspto-grants-1993_07 |