Diisobutylaluminum hydride → HCID 54475351, compound

Participants

Reaction Conditions

Reaction Steps

The ester prepared in 1F (0.39 g, 1.18 mmoles) in anhydrous ether 5 ml was added at -78° C. to a mixture of DIBAL, 1M solution in hexane, (2.5 mL) and ether (20 ml). The mixture was stirred 30 min. at -78° C., the overnight at room temperature. The excess of DIBAL was destroyed with methanol (2 ml) and the aluminum salts were precipitated with an aqueous saturated solution of ammonium chloride. The mixture was filtrated and the precipitate washed with ethyl acetate. The solvents were evaporated under reduced pressure. Flash chromatography over silica gel and elution with a 8:2 mixture of hexane and ethyl acetate afforded the expected alcohol as an oil (0.33 g, 92%).

Provenance & Evidence