Acetic Acid → HCID 54100099, compound

Participants

Reaction Conditions

Reaction Steps

The aldehyde prepared in 2G (0.937 g, 3.77 mmoles) was dissolved in methanol (20 ml) and cooled to 0° C. Sodium borohydride (0.071 g, 1.87 mmoles) was added and the mixture was stirred 30 min. Acetone was added to react with an excess of sodium borohydride and then the reaction mixture was acidified with acetic acid. The solvents were evaporated under reduced pressure. The residue was diluted with ether and washed with water. The organic phase was dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the title alcohol as an oil in a quantitative yield. NMR (H1, CDCl3, 60MHz) characteristic peaks 4 (t, JHH =7 Hz, 1), 5.1 (dt, JHF =21 Hz, JHH =8 Hz, 1).

Provenance & Evidence