HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-[3-(4-Cyano-3-fluorophenyl)propyl](phenylmethoxy)carboxamide → 4-(3-Aminopropyl)-2-fluorobenzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-[3-(4-Cyano-3-fluorophenyl)propyl](phenylmethoxy)carboxamide | HCID 22743232 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 4-(3-Aminopropyl)-2-fluorobenzenecarbonitrile | HCID 22743242 | 96.4% |
Reaction Steps
Scheme IIIb, step B: N-[3-(4-Cyano-3-fluorophenyl)propyl](phenylmethoxy)carboxamide (2 g, 6.4 mmol) and 10% palladium on carbon (0.5 g, 25 mole %) combined and hydrogenation was carried out in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, 4-(3-aminopropyl)2-fluorobenzenecarbonitrile, (1.1 g, 96%) as a colorless oil. Electron spray M.S. 179 (M*+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703425B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-07ce0be1389447f7ba75e21257bcd7f7 |
| Source note | uspto-grants-2004_03 |