HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 20633663, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 9-Borabicyclo(3.3.1)nonane | HCID 78966 | — |
| Reactant | benzyl N-(prop-2-en-1-yl)carbamate | HCID 562279 | — |
| Reactant | benzyl N-[3-(4-bromophenyl)propyl]carbamate | HCID 22743235 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Hydrogen Peroxide | HCID 784 | — |
| Product | HCID 20633663 | HCID 20633663 | 35.4% |
Reaction Steps
N-[3-(4-Bromophenyl)propyl](phenylmethoxy)carboxamide (1.5 g, 4.3 mmol), (phenylmethoxy)-N-eth-2-enylcarboxamide (0.92 g, 5.17 mmol, prepared in example 8), 9-BBN-dimer (0.84 g, 3.45 mmol), [1,1′bis(diphenylphosphino)-ferrocene] dichloropalladium (11), PdCl2(dppf), (0.175 9, 0.22 mmol), 3N sodium hydroxide (3 mL), and pH=7 buffer hydrogen peroxide (2:1, 10 mL) were combined in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, (phenylmethoxy)-N-[3-(4-{2-[(phenylmethoxy)carbonylamino]ethyl}phenyl)propyl]carboxamide, (0.68 g, 35%). Electron spray M.S. 447 (M*+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703425B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-562cb8c395cf4619985de4d69aac1107 |
| Source note | uspto-grants-2004_03 |