1,8-Diazabicyclo(5.4.0)undec-7-ene → [(Methylethyl)sulfonyl]{2-[4-(3-{[(methylethyl)sulfonyl]amino}propyl)phenyl]propyl}amine

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Reaction Steps

Scheme Vc, step C: {2-[4-(3-Aminopropyl)phenyl]propyl}[(methylethyl)sulfonylamine (0.3 g, 1 mmol, prepared in example 10), isopropylsulfonyl chloride (0.12 mL, 1.06 mmol), and DBU (0.2 mL, 1.17 mmol) were combined and sulfonylation was carried out in a manner analogous to the procedure described in example 2 to provide the title compound, [(methylethyl)sulfonyl]{2-[4-(3-{[(methylethyl)sulfonyl]amino}propyl)phenyl]propyl}amine, (0.17 g, 42%) as a white crystalline solid. Electron spray M.S. 405 (M*+H). Analysis for C18H32N2O4S2:

Provenance & Evidence