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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 483772Generated: October 30, 2026

1,1'-Carbonyldiimidazole → 3-ethyl-N-(tetrahydro-1H-pyrrolizin-7a(5H)-ylmethyl) indolizine-1-carboxamide

https://huagongshe.com/reaction/483772

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
Reactant(Hexahydro-1H-pyrrolizin-7A-YL)methanamineHCID 10654304—
Reactant3-Ethylindolizine-1-carboxylic acidHCID 14788272—
SolventDimethylformamideHCID 6228—
Product3-ethyl-N-(tetrahydro-1H-pyrrolizin-7a(5H)-ylmethyl) indolizine-1-carboxamideHCID 15229155—

Reaction Steps

3-Ethylindolizine-1-carboxylic acid is reacted with carbonyldiimidazole in dimethylformamide and subsequently with 7a-aminomethylhexahydro-1H-pyrrolizine to afford the title compound upon workup.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05227377
Source datasetuspto-grants-1993_07
ORD IDord-d74bda3367e84a6b9bf546b99313a1ec
Source noteuspto-grants-1993_07