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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 483773Generated: October 30, 2026

1,1'-Carbonyldiimidazole → N-(tetrahydro-1H-pyrrolizin-7a(5H)-ylmethyl)imidazo[1,2-a]pyridine-2-carboxamide

https://huagongshe.com/reaction/483773

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
ReactantImidazo[1,2-a]pyridine-2-carboxylic acidHCID 2062168—
Reactant(Hexahydro-1H-pyrrolizin-7A-YL)methanamineHCID 10654304—
SolventDimethylformamideHCID 6228—
ProductN-(tetrahydro-1H-pyrrolizin-7a(5H)-ylmethyl)imidazo[1,2-a]pyridine-2-carboxamideHCID 9817290—

Reaction Steps

Imidazo[1,2-a]pyridine-2-carboxylic acid is reacted with carbonyldiimidazole in dimethylformamide and subsequently with 7a-aminomethylhexahydro-1H-pyrrolizine to afford the title compound upon workup.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05227377
Source datasetuspto-grants-1993_07
ORD IDord-908ff12883c643148f0ce2eb54cbbba0
Source noteuspto-grants-1993_07