Acetic Anhydride → HCID 15157701, compound

HRID 483777Notes

Reaction equation

HRID 483777 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH:16]2[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]2)[CH2:12]1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>N1C=CC=CC=1>[C:19]([O:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH:16]2[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]2)[CH2:12]1)(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 98346891H-Indol-5-ol, 3-(1-azabicyclo[2.2.2]oct-3-yl)-

Product 1

HCID 15157701HCID 15157701, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

200 mg of 3-(5-hydroxy-3-indolyl)quinuclidine are dissolved in 10 ml of pyridine and 5 ml of acetic anhydride are added with cooling. After one hour, the mixture is worked up as is customary. 3-(5-acetoxy-3-indolyl)quinuclidine is obtained.

Workup

  1. temperaturewith cooling

Sources & evidence

ORD record
ord-f31d5a51df67437d94123c2a9c687454
Source dataset
uspto-grants-1993_07
Patent number
US05227386

Reaction notes

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