n-{2-[4-(1-Methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]ethyl}(phenylmethoxy)carboxamide → {2-[4-(2-Aminoethyl)phenyl]propyl}[(methylethyl)sulfonyl]amine

Participants

Reaction Steps

Scheme Va, step B: N-{2-[4-(1-Methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]ethyl}(phenylmethoxy)carboxamide (0.6 g, 1.44 mmol) and 10% palladium on carbon (0.5 g, 35 mole %) were combined and hydrogenation was carried out in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, {2-[4-(2-aminoethyl)phenyl]propyl}[(methylethyl)sulfonyl]amine, (0.15 g, 37%) as colorless oil. Electron spray M.S. 285 (M*+H).

Provenance & Evidence