2-Bromoethyl ethyl ether → 1-(2-Ethoxyethyl)-4-cyano-4-phenyl-piperidine

HRID 483797노트

반응식

HRID 483797 반응식
[C:1]([C:3]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)#[N:2].[CH2:15]([O:17][CH2:18][CH2:19]Br)[CH3:16]>>[CH2:15]([O:17][CH2:18][CH2:19][N:6]1[CH2:5][CH2:4][C:3]([C:1]#[N:2])([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)[CH3:16]

참가 물질

3

반응물 2

HCID 611412-Bromoethyl ethyl etherHCID 1811384-Piperidinecarbonitrile, 4-phenyl-

생성물 1

HCID 189578131-(2-Ethoxyethyl)-4-cyano-4-phenyl-piperidine

실험 절차

The title compound was prepared as described in Example I 2 from 4-cyano-4-phenylpiperidine and 2-bromoethyl ethyl ether excluding KI: Reaction time under reflux 6 hours. The compound boiled at 130°-135°/0.005 mm Hg.

후처리

  1. customReaction time
  2. temperatureunder reflux 6 hours

출처 및 근거

ORD 기록
ord-ce9dad50c54a49b78ff270fedfd9f16e
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05227389

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