Epichlorohydrin → HCID 20081652, compound

HRID 483843Notes

Reaction equation

HRID 483843 reaction equation
[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[CH:6]1([CH2:12][NH2:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>CO>[CH:6]1([CH:12]([CH:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[NH:13][CH2:4][CH:3]([OH:5])[CH2:1][Cl:2])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 7835EpichlorohydrinHCID 76688Cyclohexanemethylamine

Product 1

HCID 20081652HCID 20081652, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6.7 Grams of epichlorohydrin and 10.2 g of cyclohexylmethylamine are dissolved in 50 ml of methanol. The mixture is stirred for 8 hours at room temperature. Methanol is removed by evaporation under reduced pressure. The resulting crude oily substance is purified by a silica gel column chromatography (chloroform:methanol =8:1) to obtain 8.2 g of N-(dicyclohexylmethyl)-N-(3-chloro-2-hydroxypropyl)amine.

Workup

  1. customMethanol is removed by evaporation under reduced pressure
  2. customThe resulting crude oily substance is purified by a silica gel column chromatography (chloroform:methanol =8:1)

Sources & evidence

ORD record
ord-15b3e1c45ddc4a9e95fd02c868e7cbc6
Source dataset
uspto-grants-1993_07
Patent number
US05227381

Reaction notes

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