(Phenylmethoxy)-n-[2-(5-{2-[(phenylmethoxy)carbonylamino]ethyl}naphthyl)ethyl]carboxamide → 2-[5-(2-Aminoethyl)naphthyl]ethylamine
Reaction equation
C1(COC([NH:11][CH2:12][CH2:13][C:14]2[C:23]3[C:18](=[C:19]([CH2:24][CH2:25][NH:26]C(OCC4C=CC=CC=4)=O)[CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)=O)C=CC=CC=1>[Pd]>[NH2:11][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:23]=1[CH:22]=[CH:21][CH:20]=[C:19]2[CH2:24][CH2:25][NH2:26]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Scheme IVa, step B: (Phenylmethoxy)-N-[2-(5-{2-[(phenylmethoxy)carbonylamino]ethyl}naphthyl)ethyl]carboxamide (0.6 g, 1.24 mmol) and 10% palladium on carbon (0.5 g, 83 mole %) were combined and hydrogenation was carried out in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, 2-[5-(2-aminoethyl)naphthyl]ethylamine, (0.12 g, 44%) as a colorless oil. Electron spray M.S. 215 (M++H).
Sources & evidence
- ORD record
- ord-130286b7023645a9ae271697a14e8183
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06703425B2
Reaction notes
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