HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Phthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-(1,3-dioxoisoindolin-2-yloxy)acetate | HCID 12919120 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Phthalimide | HCID 6809 | — |
Reaction Steps
To a solution of 2.77 g of N-(t-butoxy carbonylmethoxy) phthalimide (Compound (13)) in 10 ml of anhydrous methylene chloride was added dropwise 1.37 g of trifluoro acetic acid, and the mixture was followed by stirring at room temperature over night. After the reaction was completed, the resultant was filtrated to give 520 mg of N-(corboxy methoxy) phthalimide (Compound (11)) in the form of white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05228899 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-e867207163914011a402285c752a2b81 |
| Source note | uspto-grants-1993_07 |