反应详情

Methyl (3-phenylphenoxy)acetate (6.0 g) and methyl formate (30.2 ml) were dissolved in DMF and added dropwise with stirring to a suspension of sodium hydride (1.44 g, 50% dispersion in oil) in DMF at 0° C. (ice-bath). After 45 minutes, the ice-bath was removed and the reaction mixture was stirred for 2 hours at room temperature. Aqueous sodium carbonate was then added. The aqueous layer was washed with ether, acidified to pH 4-5 with concentrated hydrochloric acid and then re-extracted with ether. The combined organic layers were washed with brine, dried, filtered and evaporated to give methyl 3-hydroxy-2-(3'-phenylphenoxy)propenoate as a pale yellow oil (6.05 g, 90% yield).

1. additionadded dropwise
2. customthe ice-bath was removed
3. additionAqueous sodium carbonate was then added
4. washThe aqueous layer was washed with ether
5. extractionre-extracted with ether
6. washThe combined organic layers were washed with brine
7. customdried
8. filtrationfiltered
9. customevaporated