HCID 67764497, compound → Propylene Oxide

HRID 484005Notes

Reaction equation

HRID 484005 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:6][NH:7][CH2:8][C@H:9]([OH:22])[CH2:10][P:11]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:13])[OH:12]>C(O)C>[CH2:8]1[O:22][CH:9]1[CH3:10].[Cl:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:6][NH:7][CH2:8][C@H:9]([OH:22])[CH2:10][P:11]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:12])[OH:13]

Participants

4

Reactant 1

HCID 67764497HCID 67764497, compound

Product 2

HCID 6378Propylene OxideHCID 18652797HCID 18652797, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner analogous to that described in Preparation Example 2 3-(3,4-dichlorobenzylamino)-2(S)-hydroxy-propyl(p-methylbenzyl)phosphinic acid hydrochloride can be manufactured. Dissolution in ethanol and treatment with propylenoxide yields 3-(3,4-dichlorobenzylamino)-2(S)-hydroxy-propyl(p-methylbenzyl)phosphinic acid of m.p. 222.5°-224°

Sources & evidence

ORD record
ord-9ba4691cd5b545fe9e196aecb6c4a35a
Source dataset
uspto-grants-1993_07
Patent number
US05229379

Reaction notes

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