Hexamethyldisilazane → Lithium Hexamethyldisilazide

Participants

Reaction Conditions

Reaction Steps

A solution of lithium bistrimethylsilylamide was prepared as follows. To hexamethyldisilazane (4.04 Kg, 5.28 L, 25 mol) was added anhydrous THF (4 L). The solution was cooled to -5° C. and n-BuLi (2.4M in hexanes, 9.7 L) was added over a period of 1.5 hr, while maintaining the reaction temperature between -5° and 0° C. The mixture was then aged for 10-15 min, allowed to rise to room temperature and stored under N2 overnight.

Provenance & Evidence