反应详情

4-cyano-5-ethoxymethyleneaminooxazole (240 mg, 1.5 mmol) (see, J. Am. Chem. Soc., 88, 3829 (1966), Bull. Chem. Soc. JAPAN, 43, 187 (1970), Bull. Chem. Soc. JAPAN, 43, 3909 (1970)) and 2-aminoindan (580 mg, 4.4 mmol) in dry ethanol (2 ml) were heated to reflux for 6.5 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by silica gel chromatography (methylene chloride:ethyl acetate=1:4) to obtain the title compound (56 mg, 0.22 mmol) having the following physical properties:

1. temperatureto reflux for 6.5 hours
2. customThe residue obtained
3. distillationby distilling off the solvent under reduced pressure
4. customwas purified by silica gel chromatography (methylene chloride:ethyl acetate=1:4)