P-Anisidine → HCID 14881088, compound

Participants

Reaction Steps

N,N'-Carbonyldiimidazole (3.85 g) and 2 g of 2-pyrrolidinone were added to 20 ml of tetrahydrofuran, and the mixture was refluxed with heating for 8 hours. Next, 2.9 g of 4-methoxyaniline was added to the reaction mixture, and the mixture was further refluxed with heating for 8 hours. The solvent was then distilled off, and the resulting residue was subjected to silica gel column chromatography to obtain a chloroform eluate and crystals from, the eluate. The crystal were recrystallized from methanol, giving 4.7 g of 1-(4-methoxyphenylcarbamoyl)-2-pyrrolidinone (yield 85%) having a melting point of 113° to 114° C.

Provenance & Evidence