反应详情

4-cyano-5-ethoxymethyleneamino-3-aminoisoxazole (320 mg, 1.8 mmol) (see J. Org. Chem., 29, 2116 (1964)) and 2-aminoindan (710 mg, 5.3 mmol) in dry ethanol (3 ml) were heated to reflux for 1.5 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by silica gel chromatography (hexane:ethyl acetate=2:1). The product obtained was crystallized from ethanol to obtain the title compound (270 mg, 0.38 mmol) having the following physical properties:

1. temperatureto reflux for 1.5 hours
2. customThe residue obtained
3. distillationby distilling off the solvent under reduced pressure
4. customwas purified by silica gel chromatography (hexane:ethyl acetate=2:1)
5. customThe product obtained
6. customwas crystallized from ethanol