Iodoethane → HCID 19750840, compound

Participants

Reaction Conditions

Reaction Steps

To 25 ml of N,N-dimethylformamide is added 0.48 g of 60% sodium hydride followed by the dropwise addition of a solution of 1.976 g of 6-(methylsulfonyl)-benz[cd]indol-2(1H)-one (Example 3) in 50 ml of N,N-dimethylformamide. Stirring is continued for 20 minutes followed by heating at 50° C. for 10 minutes then cooling at room temperature. A solution of 1.872 g of ethyl iodide in 25 ml of N,N-dimethylformamide is added dropwise and stirring continued for 1.5 hours. The reaction mixture is poured over cracked ice and the solid collected, dried and crystallized from ethyl acetate to give 1.03 g of the desired product as a solid, m.p. 199°-203° C.

Provenance & Evidence