HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(3-Chlorophenyl)piperazine monohydrochloride | HCID 25681 | — |
| Reactant | 3-(4-Bromobutyl)-2-methyl-4-thiazolidinone | HCID 10490993 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone hydrochloride | HCID 14856141 | — |
Reaction Steps
To a solution of 2-methyl-3-(4-bromobutyl)-4-thiazolidinone (4.0 g) and 1-(3-chlorophenyl)piperazine hydrochloride (3.69 g) in 100 ml of dry CH3CN were added K2CO3 (8.8 g) and NaI (200 mg). The mixture was heated to reflux with stirring under N2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05229388 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-cdb7f52b6fce491cb6a68b9af66b91eb |
| Source note | uspto-grants-1993_07 |