HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 484149Erstellt: 25. Oktober 2026
Sodium Iodide → 3-(4-(1-(6-Chlorobenzo[b]thiophen-3-yl)-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone hydrochloride
https://huagongshe.com/reaction/484149
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Iodide | HCID 5238 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| Edukt | 1-(6-Chlorobenzo[b]thien-3-yl)-piperazine | HCID 15541460 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 3-(4-(1-(6-Chlorobenzo[b]thiophen-3-yl)-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone hydrochloride | HCID 21706588 | 43% |
Reaktionsschritte
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (5.00 g), 6-chloro-3-piperazinylbenzo[b]thiophene (5.41 g), K2CO3 (8.63 g) and NaI (400 mg) in acetonitrile (200 ml) was heated at 90° C. for 16.5 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.25 g of powder, m.p. 199°-202° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US05229388 |
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| Quelldatensatz | uspto-grants-1993_07 |
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| ORD ID | ord-a33e3aa000fc4145b3beba2b2264bf55 |
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| Quellennotiz | uspto-grants-1993_07 |
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