HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 484150Generated: October 25, 2026
Sodium Iodide → 3-(4-(1-[1-Phenyl-1H-indol-3-yl]-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone dihydrochloride
https://huagongshe.com/reaction/484150
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| Reactant | 1-(1-phenyl-1H-indol-3-yl)piperazine dihydrochloride | HCID 21706602 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-[1-Phenyl-1H-indol-3-yl]-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone dihydrochloride | HCID 14856160 | 45.8% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (5.00 g), 1-(1-phenyl-1H-indol-3-yl)piperazine dihydrochloride (7.80 g), N,N-diisopropylethylamine (9.65 g), NaI (350 mg) in acetonitrile (250 ml) was heated at 75° C. for 17 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.80 g of crystals, m.p. 217°-219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05229388 |
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| Source dataset | uspto-grants-1993_07 |
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| ORD ID | ord-12b29f5583354f488c654ae188d70512 |
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| Source note | uspto-grants-1993_07 |
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