HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 484151Generated: October 25, 2026
Sodium Iodide → 3-(4-(1-[1,2-Benzisothiazol-3-yl]-4-piperazinyl)-butyl)-2,5,5-trimethyl-4-thiazolidinone hydrochloride
https://huagongshe.com/reaction/484151
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| Reactant | 1-(1,2-Benzisothiazol-3-yl)piperazine 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride | HCID 21706630 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-[1,2-Benzisothiazol-3-yl]-4-piperazinyl)-butyl)-2,5,5-trimethyl-4-thiazolidinone hydrochloride | HCID 14856150 | 61.3% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (4.70 g), 1-(1,2-benzisothiazol-3-yl)piperazine 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (4.72 g), K2CO3 (8.13 g) and NaI (300 mg) in acetonitrile (200 ml) was heated at 65° C. for 16 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.77 g of crystals, m.p. 209°-214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05229388 |
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| Source dataset | uspto-grants-1993_07 |
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| ORD ID | ord-5caa3f08ee3848bc8c832ea4442baeb4 |
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| Source note | uspto-grants-1993_07 |
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