HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 484155Generated: October 29, 2026
Sodium Iodide → 3-(4-(1-(6-Chlorobenzo[b]thiophen-3-yl)-4-piperazinyl)butyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one hydrochloride
https://huagongshe.com/reaction/484155
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(4-Bromobutyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10780950 | — |
| Reactant | 1-(6-Chlorobenzo[b]thien-3-yl)-piperazine | HCID 15541460 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-(6-Chlorobenzo[b]thiophen-3-yl)-4-piperazinyl)butyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one hydrochloride | HCID 14856178 | 27.5% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one (5.00 g), 6-chloro-3-piperazinylbenzo[b]thiophene (5.10 g), K2CO3 (8.00 g) and NaI (400 mg) in acetonitrile (250 ml) was heated at 85° C. for 15.5 hours and the product was processed in substantially the same manner as in Example 10 to afford 1.43 g of crystalline solid, m.p. 211°-214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05229388 |
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| Source dataset | uspto-grants-1993_07 |
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| ORD ID | ord-4eabe4d8eb094d10af6285edf7e57c54 |
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| Source note | uspto-grants-1993_07 |
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