HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 3-(4-(1-(1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(4-Bromobutyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10780950 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride | HCID 11521711 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-(1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one hydrochloride | HCID 14856179 | 47.4% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one (3.84 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (3.49 g), K2CO3 (5.90 g) and NaI (280 mg) in acetonitrile (215 ml) was heated at between 65°-80° C. for 16.5 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.86 g of crystals, m.p. 210°-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05229388 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-0abc561256f84b57b0df1a9fa8847c1b |
| Source note | uspto-grants-1993_07 |