HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 484158Generated: October 29, 2026
Sodium Iodide → 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-1-thia-3-azaspiro[4.5]decan-4-one hydrochloride
https://huagongshe.com/reaction/484158
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chloro-1,2-benzisothiazol-3-yl piperazine | HCID 10491125 | — |
| Reactant | 3-(4-Bromobutyl)-1-thia-3-azaspiro[4.5]decanone | HCID 56996022 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-1-thia-3-azaspiro[4.5]decan-4-one hydrochloride | HCID 14856185 | 76.6% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-1-thia-3-azaspiro[4.5]decanone (2.7 g), 6-chloro-1,2-benzisothiazol-3-yl piperazine (2.0 g), K2CO3 (2.2 g) and NaI (200 mg) in acetonitrile (100 ml) was heated at 80° C. for 8 hours and the product was processed in substantially the same manner as in Example 10 to afford 1.557 g of solid, m.p. 202°-205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05229388 |
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| Source dataset | uspto-grants-1993_07 |
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| ORD ID | ord-db43ad1d914b451d8a27ac6c4183f141 |
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| Source note | uspto-grants-1993_07 |
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